Invitrogen™ Phospho-KSR2 (Thr497) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5105093

Product Code. 16601545

Description

Antibody detects endogenous levels of KSR2 only when phosphorylated at Thr497.

KSR2 serine/threonine kinase or kinase suppressor of Ras 2 specifically regulates the activity of MEKK3 and COT but not other members of the MAP3K family. KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans. Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Specifications

• Antigen: Phospho-KSR2 (Thr497)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KSR2
• Gene Alias: hKSR2; Kinase suppressor of Ras 2; ksr2; RGD1562674; testes-kinase suppressor of ras 2 isoform
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 283455, 288691, 333050
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q3UVC0, Q6VAB6
• Gene Symbols: KSR2
• Immunogen: A synthesized peptide derived from human KSR2(Accession Q6VAB6), corresponding to amino acid residues around phosphorylated Thr497.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG