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Phospho-JNK1/JNK2/JNK3 (Thr183, Tyr185) Polyclonal Antibody, Invitrogen™

Product Code. 15555211
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Quantity:
100 μg
Unit Size:
100µg
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15555211 100 μg 100µg
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Product Code. 15555211 Supplier Invitrogen Supplier No. PA538288

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Description

Rabbit Polyclonal Antibody

The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regulation. JNK3 is crucial for neuronal apoptosis (stress-induced).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-JNK1/JNK2/JNK3 (Thr183, Tyr185)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MAPK9
Gene Accession No. P45983, P45984, P53779, Q61831, Q91Y86, Q9WTU6, P49185, P49186, P49187
Gene Alias JNK 46, JNK 55, JNK, JNK1, JNK1A2, JNK2, JNK21B1/2, JNK2ALPHA, JNK2B, JNK2BETA, JNK3, JNK3A, MAP kinase 8, MAP kinase 9, MAP kinase p49 3F12, MAPK 8, MAPK 9, MAPK10, MAPK8, MAPK9, MGC50974, Mitogen activated protein kinase 10, Mitogen activated protein kinase 8, Mitogen activated protein kinase 9, JNK3; JNK3A; PRKM10; p54bSAPK; MAPK10, Phospho-JNK
Gene Symbols MAPK10, MAPK8, MAPK9
Host Species Rabbit
Immunogen A synthetic phosphopeptide derived from human JNK1/2/3 around the phosphorylation site of Thr183/Tyr185 (M-M-TP-P-YP-V-V)
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116554, 25272, 26414, 26419, 26420, 50658, 5599, 5601, 5602
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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