Phospho-IP3 Receptor 1 (Ser1764) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA539790

Product Code. 15526661

Description

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

Specifications

• Antigen: Phospho-IP3 Receptor 1 (Ser1764)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ITPR1
• Gene Alias: Inositol 1,4,5,-Triphosphate Receptor Type I, IP3R, IP3R1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16438, 25262, 3708
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q14643, P11881, P29994
• Gene Symbols: ITPR1
• Immunogen: A synthetic phosphopeptide derived from human IP3R1 around the phosphorylation site of Ser1764 (R-E-SP-L-T)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG