Invitrogen™ Phospho-INCENP (Thr59) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5106183

Product Code. 16622625

Description

Antibody detects endogenous levels of INCENP only when phosphorylated at Thr59.

Chromosomal passenger proteins are members of a group of proteins that move from centromeres to the spindle midzone during mitosis. INCENP (Inner Centromere Protein) is a chromosomal passenger protein with an essential role in mitosis and meiosis. It is a complex highly basic multidomain protein that is dynamically translocated from metaphase chromosomes to the spindle midzone during or just prior to anaphase. Some INCENP transfers to the equatorial cortex before formation of the cleavage furrow. Ultimately, it is discarded in the midbody at the completion of cytokinesis.

Specifications

• Antigen: Phospho-INCENP (Thr59)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Incenp
• Gene Alias: 2700067E22Rik; AU019509; binds and activates aurora-B and -C in vivo and in vitro; C130081E20; C77457; chromosomal passenger protein; Incenp; Inner centromere protein; inner centromere protein antigens 135/155kDa; inner centromere protein INCENP
• Host Species: Rabbit
• Purification Method: Sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16319, 293733, 3619
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9NQS7, Q9WU62
• Gene Symbols: Incenp
• Immunogen: A synthesized peptide derived from human INCENP(Accession Q9NQS7), corresponding to amino acid residues around phosphorylated Thr59.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG