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Invitrogen™ Phospho-Glucocorticoid Receptor (Ser211) Polyclonal Antibody
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Product Code. 16520222
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
16520222 100 μL 100µL
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Product Code. 16520222 Supplier Invitrogen™ Supplier No. PA597386

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: NESPW; Positive Samples: HeLa; Cellular Location: Cytoplasm, Mitochondrion, Nucleus, Nucleus.

Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. GR binds to known steroids such as dexamethasone with nanomolar affinity.
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Specifications

Antigen Phospho-Glucocorticoid Receptor (Ser211)
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.74 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Nr3c1
Gene Accession No. P04150, P06537
Gene Alias cytosolic/nuclear receptor; fb13f09; GCCR; Gcr; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor alpha; GR; gr alpha; GR Kit; Grl; Grl1; Grl-1; Nr3c1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858; utouto; utut; wu:fb13f09; zgc:113038
Gene Symbols Nr3c1
Host Species Rabbit
Immunogen A synthetic phosphorylated peptide around S211 of human Glucocorticoid Receptor (NP_0001671).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14815, 2908
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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