Invitrogen™ Phospho-DNA-PK (Ser2056) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA578130

Product Code. 16366834

Description

Positive Control: 293T, 293T (100 J/m2 UVC treatment) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.

Specifications

• Antigen: Phospho-DNA-PK (Ser2056)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRKDC
• Gene Alias: AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5591
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ChIP Assay, Western Blot, Immunocytochemistry
• Concentration: 1.33 mg/mL
• Formulation: PBS with 20% glycerol, 1% BSA and 0.025% ProClin 300; pH 7
• Gene Accession No.: P78527
• Gene Symbols: PRKDC
• Immunogen: Carrier-protein conjugated synthetic peptide surrounding phospho Ser2056 of human DNA-PKcs. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG