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Invitrogen™ Phospho-DARPP-32 (Thr75) Polyclonal Antibody
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Product Code. 16641485
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Quantity:
100 μL
Unit Size:
100µL
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16641485 100 μL 100µL
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Product Code. 16641485 Supplier Invitrogen™ Supplier No. PA5105037

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of DARPP32 only when phosphorylated at Threonine 75.

DARPP-32 is a dopamine (DA) and AMP-regugated ~32 kDa phosphoprotein that is associated with dopaminoceptive neurons. The protein inhibits Protein Phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP-32 is thought to play a critical role in the regugation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac®.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-DARPP-32 (Thr75)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Ppp1r1b
Gene Accession No. Q60829, Q6J4I0, Q9UD71
Gene Alias AU040756; DARPP32; DARPP-32; dopamine- and cAMP-regulated neuronal phosphoprotein; dopamine and cAMP-regulated neuronal phosphoprotein 32; dopamine- and cAMP-regulated phosphoprotein DARPP-32; FLJ20940; IPPD; neuronal phosphoprotein DARPP-32; OTTHUMP00000164275; OTTHUMP00000164276; Ppp1r1b; PPR1B; protein pho; protein phosphatase 1 regulatory inhibitor subunit 1B; protein phosphatase 1 regulatory subunit 1B; protein phosphatase 1, regulatory (inhibitor) subunit 1B
Gene Symbols Ppp1r1b
Host Species Rabbit
Immunogen A synthesized peptide derived from human PPP1R1B(Accession Q9UD71), corresponding to amino acid residues around phosphorylated Thr75.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19049, 360616, 84152
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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