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Phospho-Cyclin E2 (Thr392) Polyclonal Antibody, Invitrogen™

Product Code. 15585381
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Quantity:
100 μg
Unit Size:
100µg
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15585381 100 μg 100µg
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Product Code. 15585381 Supplier Invitrogen Supplier No. PA538462

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Description

Rabbit Polyclonal Antibody

The human Cyclin E2 gene encodes a 404 amino acid protein that is most closely related to Cyclin E. Cyclin E2 mRNA levels peaks at the G1 / S transition. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27 (Kip1) and p21 (Cip1). Cyclin E2 / Cdk2 phosphorylates histone H1 in vitro. G1 cyclin E controls the initiation of DNA synthesis by activating CDK2. Abnormally high levels of cyclin E expression have frequently been observed in human cancers. Unlike Cyclin E1, which is expressed in great majority of proliferating normal and neoplastically transformed cells, Cyclin E2 levels are low to undetectable in non transformed cells and increase significantly in neoplasm derived cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Cyclin E2 (Thr392)
Applications Peptide ELISA, Immunofluorescence
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CCNE2
Gene Accession No. O96020, Q9Z238
Gene Alias CYCE2
Gene Symbols CCNE2
Host Species Rabbit
Immunogen A synthetic phosphopeptide derived from human Cyclin E2 around the phosphorylation site of Thr392 (I-M-TP-P-P)
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12448, 9134
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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