Invitrogen™ Phospho-Cyclin D3 (Thr283) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5104862

Product Code. 16654365

Description

Antibody detects endogenous levels of Cyclin D3 only when phosphorylated at Threonine 283.

The protein encoded by this gene belongs to the highly conservedcyclinfamily, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.Cyclins function as regulators of CDK kinases. Differentcyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Thiscyclinforms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with thiscyclinwas reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. Diseases associated with CCND3 include Retinoblastoma and Plasma Cell Leukemia.

Specifications

• Antigen: Phospho-Cyclin D3 (Thr283)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCND3
• Gene Alias: 9230106B05Rik; AA682053; AL024085; AW146355; C78795; CCND 3; Ccnd3; CGD3; cyclin D3; CyclinD3; Cyl-3; D3 type cyclin; D3-type cyclin; G1/S-specific cyclin-D3; OTTHUMP00000223415; RP5-973N23.3
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12445, 25193, 896
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P30281, P30282, P48961
• Gene Symbols: CCND3
• Immunogen: A synthesized peptide derived from human CCND3(Accession P30281), corresponding to amino acid residues around phosphorylated Thr283.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG