Invitrogen™ Phospho-CRMP2 (Thr555) Monoclonal Antibody (M539)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA547623

Product Code. 17816928

Description

The antibody detects a 70 kDa* protein corresponding to CRMP2 on immunoblots of rat PC12 or mouse C2C12 cells treated with calyculin A. This reactivity is not observed after lambda phosphatase dephosphorylation of Thr-555.

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.

Specifications

• Antigen: Phospho-CRMP2 (Thr555)
• Classification: Monoclonal
• Concentration: 2 mg/mL
• Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
• Gene Accession No.: O08553, P47942, Q16555
• Gene Symbols: DPYSL2
• Immunogen: Clone M539 was generated from a phospho-CRMP2 (Thr-555) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding Thr-555 in human CRMP2. This sequence is conserved in rat and mouse CRMP2 and the phospho-site is not conserved in other CRMP family members.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: M539
• Conjugate: Unconjugated
• Gene: DPYSL2
• Gene Alias: AI851130; collapsin response mediator protein 2; collapsin response mediator protein hCRMP-2; CRMP2; CRMP-2; DHPRP2; dihydropyrimidinase like 2; dihydropyrimidinase-like 2; dihydropyrimidinase-related protein 2; DPYL2; Dpysl2; DRP2; DRP-2; Musunc33; N2A3; Neural-specific protein NSP60; TOAD-64; turned on after division 64; turned on after division 64 kDa protein; turned on after division, 64 kDa protein; ULIP2; ULIP-2; unc-33-like phosphoprotein 2; Unknown (protein for MGC:137406)
• Host Species: Mouse
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12934, 1808, 25416
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid