Invitrogen™ Phospho-Cofilin (Ser3) Monoclonal Antibody (G.577.4)

Rabbit Monoclonal Antibody

Brand:  Invitrogen™ MA515038

Product Code. 11595001

Description

It is not recommended to aliquot this antibody.

Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration.

Specifications

• Antigen: Phospho-Cofilin (Ser3)
• Classification: Monoclonal
• Concentration: 42 μg/mL
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
• Gene Accession No.: P18760, P23528, P45592, Q5E9F7
• Gene Symbols: CFL1
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pSer3 of human cofilin.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Monkey, Bovine
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry
• Clone: G.577.4
• Conjugate: Unconjugated
• Gene: CFL1
• Gene Alias: 18 kDa phosphoprotein; AA959946; CFL; Cfl1; CFL-1; Cof; COF1; cofilin; cofilin 1; cofilin 1 (non-muscle); cofilin 1, non-muscle; cofilin, non-muscle isoform; Cofilin1; Cofilin-1; cofilin-1-like protein; epididymis secretory protein Li 15; HEL-S-15; n-cofilin; p18
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1072, 12631, 29271, 534553
• Content And Storage: -20°C
• Form: Liquid