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Invitrogen™ Phospho-Chk2 (Thr68) Recombinant Rabbit Monoclonal Antibody (Chk2T68-D12), APC, Invitrogen™
Rabbit Recombinant Monoclonal Antibody
£184.00 - £463.00
Specifications
| Antigen | Phospho-Chk2 (Thr68) |
|---|---|
| Clone | Chk2T68-D12 |
| Applications | Flow Cytometry |
| Classification | Recombinant Monoclonal |
| Conjugate | APC |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
17166858
|
Invitrogen™
MA537270 |
10 Tests |
£184.00
Pack of 10 |
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|
17146578
|
Invitrogen™
MA536988 |
100 Tests |
£463.00
Pack of 100 |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.Specifications
| Phospho-Chk2 (Thr68) | |
| Flow Cytometry | |
| APC | |
| Rabbit | |
| Human, Mouse | |
| O96017, Q9Z265 | |
| 11200, 50883 | |
| A synthetic phosphor-peptide corresponding to residues surrounding to Thr68 of human phospho Chk2. | |
| Primary | |
| 4°C | |
| Chek2 |
| Chk2T68-D12 | |
| Recombinant Monoclonal | |
| Liquid | |
| RUO | |
| PBS with 0.20% BSA and 0.09% sodium azide | |
| CDS1; cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; checkpoint-like protein CHK2; Chek2; Chk2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; HuCds 1; HuCds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; Rad53; Rad53 homolog; RP11-436C9.1; Serine/threonine protein kinase Chk2; serine/threonine-protein kinase Chk2 | |
| Chek2 | |
| IgG κ | |
| Protein A/G | |
| Antibody |
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