Invitrogen™ Phospho-Chk1 (Ser345) Recombinant Rabbit Monoclonal Antibody (Chk1S345-R3F9), APC, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA537022

Product Code. 17186608

Description

CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.

Specifications

• Antigen: Phospho-Chk1 (Ser345)
• Classification: Recombinant Monoclonal
• Conjugate: APC
• Gene: Chek1
• Gene Alias: C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
• Host Species: Rabbit
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 1111, 12649, 140583
• Content And Storage: 4°C
• Form: Liquid

• Applications: Flow Cytometry
• Clone: Chk1S345-R3F9
• Formulation: PBS with 0.20% BSA and 0.09% sodium azide
• Gene Accession No.: O14757, O35280, Q91ZN7
• Gene Symbols: Chek1
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1.
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG κ