Invitrogen™ Phospho-Cdc25A (Ser178) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5104863

Artikelnummer. 16601315

Beskrivelse

Antibody detects endogenous levels of CDC25A only when phosphorylated at Serine 178.

CDC25a is a member of the CDC25 family of phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B, and CDC25C. These three genes function at different phases of the cell cycle. CDC25a is required for progression through G1 and S phases of the cell cycle. CDC25a activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated.

Tekniske data

• Antigen: Phospho-Cdc25A (Ser178)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDC25A
• Gene Alias: CDC25 isoform A1-CAG; CDC25A; CDC25A2; CDC25A2-CAG isoform; Cdc25m3; cell division cycle 25A; D9Ertd393e; dual specificity phosphatase Cdc25A; EC 3.1.3.48; M-phase inducer phosphatase 1; MPIP1
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12530, 171102, 993
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P30304, P48964, P48965
• Gene Symbols: CDC25A
• Immunogen: A synthesized peptide derived from human CDC25A(Accession P30304), corresponding to amino acid residues around phosphorylated Ser178.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG