Invitrogen™ Phospho-Btk (Tyr551) Recombinant Rabbit Monoclonal Antibody (BtkY551-G12), FITC, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
17146958	Invitrogen™ MA537368	10 Tests
17186708	Invitrogen™ MA537122	100 Tests

Descrizione

Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders. It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction.

Specifica

• Antigen: Phospho-Btk (Tyr551)
• Applications: Flow Cytometry
• Conjugate: FITC
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q06187
• Gene ID (Entrez): 695
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr551 of human phospho Btk.
• Primary or Secondary: Primary
• Content And Storage: 4°C, store in dark
• Gene: BTK

• Clone: BtkY551-G12
• Classification: Recombinant Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 0.20% BSA and 0.09% sodium azide
• Gene Alias: agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; IMD1; Kinase EMB; MGC126261; MGC126262; OTTHUMP00000023677; PSCTK1; RP1-164F3.2; truncated Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); xid; XLA; X-linked immune deficiency
• Gene Symbols: BTK
• Isotype: IgG κ
• Purification Method: Protein A/G
• Product Type: Antibody