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phospho-AKT Mouse, PE, Clone: SDRNR, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-9715-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15597216

  • £205.24 / 100 tests


Estimated Shipment date
from Supplier 04-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This SDRNR monoclonal antibody recognizes human and mouse AKT (also known as Protein Kinase B (PKB)) when phosphorylated on S473. AKT is a serine/threonine protein kinase that plays a key role in multiple cellular processes including metabolism, proliferation, apoptosis/survival, and migration. There are three homologous isoforms of AKT: AKT1, AKT2, and AKT3. AKT is activated by binding of its pleckstrin homology (PH) domain to membrane phospholipids and by phosphorylation. Phosphorylation of AKT at T308 by PDK1 and at S473 is required for full activation of this kinase. AKT promotes cell survival by inhibiting apoptosis via phosphorylation and inactivation of several targets including Bad, Foxo1, c-Raf, and caspase-9. Deregulation of AKT has been implicated as a major contributing factor in many types of cancer. AKT is negatively regulated by the phosphatase PTEN as well as by the chemical inhibitor LY294002. Specificity of this SDRNR clone was determined by ELISA, flow cytometry, and western blotting.
Description & Specifications

Specifications

phospho-AKT
SDRNR
PE
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.06μg)/test
Conjugated
Protein Kinase B (PKB)
IgG2a
RUO
Primary
Murine