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Invitrogen™ Phospho-A-Raf (Ser582) Polyclonal Antibody
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Product Code. 16681925
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
16681925 100 μL 100µL
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Product Code. 16681925 Supplier Invitrogen™ Supplier No. PA5105483

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of A-RAF only when phosphorylated at Ser582.

Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a cytoplasmic protein with intrinsic serine/threonine activity. It is broadly expressed in nearly all cell lines tested to date and is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein has been associated with transformation and mitogenesis while the activity of Raf-1 is normally suppressed by a regulatory N-terminal domain. A-Raf, a second member of the Raf gene family of serine/ threonine protein kinases, exhibits substantial homology to Raf-1 within the kinase domain of the two molecules, but less homology elsewhere. Expression of A-Raf is found at highest levels in urogenital tissues and kidney and at lowest level in brain tissue.
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Specifications

Antigen Phospho-A-Raf (Ser582)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ARAF
Gene Accession No. P04627, P10398, P14056
Gene Alias 1200013E08Rik; Araf; A-RAF; A-Raf proto-oncogene serine/threonine-protein kinase; A-Raf proto-oncogene, serine/threonine kinase; Araf1; A-raf-1; AW495444; Oncogene ARAF1; PKS; PKS2; Proto-oncogene A-Raf; proto-oncogene A-Raf-1; Proto-oncogene Pks; raf a; Raf related protein; RAFA1; raf-related oncogene; Ras-binding protein; Ras-binding protein DA-Raf; RP1-230G1.1; serine/threonine-protein kinase A-Raf; v-raf murine sarcoma 3611 viral oncogene homolog; v-raf murine sarcoma 3611 viral oncogene homolog 1; v-raf murine sarcoma 3611 viral oncogene-like protein; v-raf oncogene homolog 1 (murine sarcoma 3611 virus)
Gene Symbols ARAF
Host Species Rabbit
Immunogen A synthesized peptide derived from human ARAF(Accession P10398), corresponding to amino acid residues around phosphorylated Ser582.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11836, 369, 64363
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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