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Phospho-4E-BP1 (T36/T45) Mouse anti-Human, Mouse, eFluor 660, Clone: V3NTY24, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-9107-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15540077

  • £213.39 / 100 tests


Estimated Shipment date
from Supplier 25-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The V3NTY24 monoclonal antibody recognizes human and mouse eukaryotic translation initiation factor eIF4E-binding protein 1 (4E-BP1) when phosphorylated at threonine 37 and/or threonine 46. 4E-BP1 is a member of a family of translation repressor proteins that include 4E-BP2 and 4E-BP3. In its non-phosphorylated form, 4E-BP1 binds to the eIF4E translation initiation factor and represses cap-dependent translation. Phosphorylation of 4E-BP1 at multiple sites is necessary to disrupt this interaction and de-repress cap-dependent translation. Studies have identified several kinases that phosphorylate 4E-BP1. For instance, FRAP/mTOR phosphorylates Thr37 and Thr46, while ATM phosphorylates Ser111. Phosphorylation of 4E-BP1 at Thr37 and Thr46 is inhibited by the PI3 kinase inhibitors LY294002 and wortmannin.
Description & Specifications

Specifications

Phospho-4E-BP1 (T36/T45)
V3NTY24
eFluor 660
Conjugated
IgG2b
RUO
Primary
Murine
Flow Cytometry (Intracellular Staining)
5μL (0.06μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal