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  5. STEMCELL Technologies Phorbol 12-myristate 13-acetate

STEMCELL Technologies Phorbol 12-myristate 13-acetate

Product Code. 17160312
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Quantity:
1 mg
5 mg
Unit Size:
1mg
5mg
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Product Code. 17160312

Brand: STEMCELL Technologies 74042

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Description

PKC pathway activator; Activates protein kinase C

  • Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a reversible, highly potent activator of protein kinase C (PKC), including Group A and Group B isoforms (Blumberg)
  • PMA activates PKC isoforms through the binding of the C1 domain (Hurley et al.) PMA can also activate certain mitogen-activated protein (MAP) kinase pathways through PKC (Adams & Parker)
  • Stimulates cardiac differentiation of mesenchymal stem cells (Seo et al.)
  • Promotes hematopoietic differentiation (Clemens et al.)
  • Stimulates differentiation of IL-15-stimulated lamina propria CD4+ T cells into CXCR5+CD4+ cells when used together with ionomicin (Sarra et al.)
  • In combination with AS101, it shows anti-leukemic activity and stimulates human leukemia cell lines to differentiate into macrophage-like cells (Glesne & Huberman; Hayun et al.)

Specifications

CAS 16561-29-8
Synonym 12-O-Tetradecanoylphorbol-13-acetate; PMA; TPA
Quantity 1 mg
Molecular Formula C36H56O8
Purity ≥98%
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