PHLDA1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA538941

Product Code. 15555851

Description

Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR). A previously undescribed protein, TDAG51, restores activation- induced apoptosis in cells that have lost the ability to display Fas in response to activation.

Specifications

• Antigen: PHLDA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PHLDA1
• Gene Alias: Pleckstrin homology-like domain family A member 1, Apoptosis-associated nuclear protein, Proline- and glutamine-rich protein, PQ-rich protein, PQR protein, Proline- and histidine-rich protein, T-cell death-associated gene 51 protein, PHLDA1, PHRIP, TDAG51
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21664, 22822, 29380
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8WV24, Q62392, Q9QZA1
• Gene Symbols: PHLDA1
• Immunogen: A synthetic peptide derived from the internal region of human PHLA1
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG