Invitrogen™ PHIP Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA554093

Product Code. 15712031

Description

Immunogen sequence: TEQPSTSSAA KTFITKANAS AIPGKTILEN SVKHSKALNT LSSPGQSSFS HGTRNNSAKE NMEKEKPVKR KMKSSVLPKA STLSKSSA Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 81%.

PHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein that contains eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (localizing to the cytosol and nucleus) and primary beta cells (localizing to the nucleus) and acts as a transcriptional activator. PHIP is known to interact with various members of the insulin receptor substrate (IRS) family. The IRS family of proteins mediate insulin receptor signaling and play an important role in insulin-producing beta cell proliferation and survival. PHIP specifically associates with the PH domain of IRS-1 and may function to link IRS-1 to insulin receptors, indicating a vital role of PHIP in the regulation of insulin signaling.

Specifications

• Antigen: PHIP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PHIP
• Gene Alias: 2810004D21Rik; 4632404O06Rik; BRWD2; DCAF14; DDB1 and CUL4 associated factor 14; DDB1- and CUL4-associated factor 14; FLJ20705; IRS-1 PH domain-binding protein; Ndrp; neuronal differentiation related protein; neuronal differentiation-related protein; PH-interacting protein; PHIP; pleckstrin homology domain interacting protein; WD repeat domain 11; WD repeat-containing protein 11; WDR11
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55023
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8WWQ0
• Gene Symbols: PHIP
• Immunogen: Recombinant protein corresponding to Human PHIP. Recombinant protein control fragment (Product #RP-92476).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG