Invitrogen™ PHD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5116563

Product Code. 17249063

Description

Positive Samples: Mouse brain, Rat heart Immunogen sequence: DGGDAPSPSK RPWARQENQE AEREGGMSCS CSSGSGEASA GLMEEALPSA PERLALDYIV PCMRYYGICV KDSFLGAALG GRVLAEVEAL KRGGRLRDGQ.

Prolyl hydroxylase domain proteins HIF PHD1, HIF PHD2 and HIF PHD3 (known as PHD1, PHD2 and PHD3 in rodents, respectively) can hydroxylate HIF-alpha subunits. Hypoxia-inducible factor (HIF) is a transcriptional regulator important in several aspects of oxygen homeostasis. The prolyl hydroxylases catalyze the posttranslational formation of 4-hydroxyproline in HIF-alpha proteins. HIF PHD1, which is widely expressed, with highest levels of expression in testis, functions as a cellular oxygen sensor and is important in cell growth regulation. HIF PHD1 can localize to the nucleus or the cytoplasm and is also detected in hormone responsive tissues, such as normal and cancerous mammary, ovarian and prostate epithelium. HIF PHD1 is encoded by EGLN2, which maps to chromosome 19q13. 3.

Specifications

• Antigen: PHD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EGLN2
• Gene Alias: 0610011A13Rik; C85656; egl nine homolog 2; egl-9 family hypoxia inducible factor 2; egl-9 family hypoxia-inducible factor 2; Egln2; EIT6; EIT-6; Estrogen-induced tag 6; falkor; HIF-1alpha prolyl-4-hydroxylase-1; HIF-P4H 1; Hif-p4h-1; HIFPH1; HIF-PH1; HIF-prolyl hydroxylase 1; HPH-1; HPH-3; Hypoxia-inducible factor prolyl hydroxylase 1; Ier4; immediate early response 4; P4H1; Phd1; PHD-1; Prolyl hydroxylase domain-containing protein 1; SM-20
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 112398, 112406, 308457
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.25 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q6AYU4, Q91YE2, Q96KS0
• Gene Symbols: EGLN2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 124-223 of human Prolyl hydroxylase PHD1 (EGLN2) (NP_4442741).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG