Invitrogen™ PGA5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5121695

Product Code. 17733094

Description

PGA5 Polyclonal Antibody for Western Blot, Flow

PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. PGA5 is inhibited by ovUS-1, a uterine serpin.

Specifications

• Antigen: PGA5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pga5
• Gene Alias: 1110035E17Rik; Pepf; pepsin A; pepsin A-5; Pepsin F; Pepsinogen 5; pepsinogen 5, group I; pepsinogen 5, group I (pepsinogen A); pepsinogen A; pepsinogen A precursor; pepsinogen A5; pepsinogen F; pepsinogen F protein; pepsinogen precursor; pepsinogen-5; Pg5; PGA; PGA3; PGA4; PGA5
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 396892, 5222, 58803
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: P0DJD9, Q9D106
• Gene Symbols: Pga5
• Immunogen: Recombinant protein Pepsinogen A. The antigen corresponds to amino acid range Val63-Phe163+Gly206-Ser295 of the target protein.
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Pig
• Product Type: Antibody
• Isotype: IgG