Invitrogen™ PFTK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA590166

Product Code. 16577701

Description

Immunogen sequence: AAFPGMKDIQ DQLERIFLVL GTPNEDTWPG VHSLPHFKPE RFTLYSSKNL RQAWNKLSYV NHAEDLASKL LQCSPKNRLS AQAALSHEYF SDLPPRLWEL TDMSSIFTVP NVRLQPEAGE SMRAFGKNNS YGKSLSNSKH; Positive Samples: Mouse testis; Cellular Location: Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein.

CDK14 (PFTK1)/cyclin Y is a member of the CDC2-related protein kinase family which is expressed primarily in the postnatal and adult nervous system. CDK14 is expressed at high levels in brain, pancreas, kidney, heart, testis, and ovary. CDK14 amino acid residue ser119 is required for its interaction with all four 14-3-3 isoforms, while ser120 may contribute slightly to CDK14 binding. CDK14 acts as a cyclin-dependent kinase that regulates cell cycle progression and cell proliferation. Overexpression of CDK14 predicts resistance to chemotherapy in patients with esophageal squamous cell carcinoma.

Specifications

• Antigen: PFTK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cdk14
• Gene Alias: Cdk14; Cell division protein kinase 14; cyclin dependent kinase 14; cyclin-dependent kinase 14; hPFTAIRE1; Kiaa0834; mKIAA0834; PFTAIRE protein kinase 1; PFTAIRE1; Pftk1; Serine/threonine-protein kinase PFTAIRE-1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18647
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.52 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O35495
• Gene Symbols: Cdk14
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 312-451 of human CDK14 (NP_0365271).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG