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  5. Tocris Bioscience™ PFI 7

Tocris Bioscience™ PFI 7

Product Code. 30279878
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 30279878

Brand: Tocris Bioscience™ 7960/50

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This item is not returnable. View return policy

Description

Selective GID4 antagonist

PFI 7 is a selective GID4 antagonist (Kd = 80 nM by SPR assays and EC50 = 0.6 μM by cell-based NanoBRET). PFI 7 binds within the ?-barrel of GID4 substrate binding pocket, disrupting its interaction with the canonical Pro/N-degron peptide in live cells. It alters protein levels of several proteins including RNA helicases as measured by quantitative proteomics.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-((1s,4s)-4-(1H-Benzo[d]imidazol-2-yl)cyclohexyl)-2-(((1H-indol-2-yl)methyl)amino)acetamide dihydrochloride
Quantity 50 mg
Target Ubiquitin Ligase (E3) Inhibitors
Molecular Formula C24H27N5O.2HCl
Purity 0.98
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