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PF-CBP1 hydrochloride, MedChemExpress

Product Code. 16433937
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Product Code. 16433937 Supplier Medchem Express Supplier No. HY19999A

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Description

MedChemExpress PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD).

PF-CBP1 inhibits CREBBP and EP300 bromodomains with IC50 of 125 nM and 363 nM respectively. PF-CBP1 hydrochloride reduces LPS-induced inflammatory cytokines expression (IL-1β, IL-6 and IFN-β) in primary macrophages. PF-CBP1 hydrochloride also downregulates RGS4 expression cortical neurons and can be used for the research of neurological disorders, including epilepsy and parkinson's disease, et al.

Specifications

Chemical Name or Material PF-CBP1 hydrochloride
CAS 2070014-93-4
Color White
Purity Grade Notes Research
Molecular Formula C29H37ClN4O3
Quantity 50 mg
Solubility Information DMSO : 100 mg/mL (190.45 mM; Need ultrasonic) ∣H2O : 1 mg/mL (1.90 mM; Need ultrasonic)
SMILES CCCOC1=CC=C(CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2CCN5CCOCC5)C=C1.Cl[H]
Molecular Weight (g/mol) 525.08
Formula Weight 525.08
Percent Purity 95.95%
Grade Research
Physical Form Powder
For Use With (Application) Neuroscience-Neurodegeneration
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Research purposes only

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