PF-543 Citrate, MedChemExpress

Product Code. 16499087

Brand: Medchem Express HY15425A

Description

MedChemExpress PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy.

PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy.

Specifications

• Chemical Name or Material: PF-543 Citrate
• CAS: 1415562-83-2
• Color: Light Yellow
• Purity Grade Notes: Research
• Molecular Formula: C₃₃H₃₉NO₁₁S
• Quantity: 5 mg
• Synonym: Sphingosine Kinase 1 Inhibitor II Citrate
• Solubility Information: DMSO : ≥ 100 mg/mL (152.04 mM) ∣H2O : 50 mg/mL (76.02 mM; Need ultrasonic)
• SMILES: OC(C(O)=O)(CC(O)=O)CC(O)=O.O=S(C1=CC=CC=C1)(CC2=CC(C)=CC(OCC3=CC=C(CN4[C@@H](CO)CCC4)C=C3)=C2)=O
• Molecular Weight (g/mol): 657.73
• Formula Weight: 657.73
• Percent Purity: 98.35%
• Grade: Research
• Physical Form: Solid
• For Use With (Application): Cancer-Kinase/protease

Research purposes only