Tocris Bioscience™ PF 05089771

Product Code. 18709248

Brand: Tocris Bioscience™ 5931/10

Description

Potent and selective Nav1.7 channel blocker

PF 05089771 is a potent and selective Nav1.7 channel blocker (IC50 = 8, 11 and 171 nM for mouse, human and rat Nav1.7, respectively). Exhibits selectivity for Nav1.7 over other Nav1 channels (IC50 values are 0.11, 0.16, 0.85, 10, 11 and 25 μM for Nav1.2, Nav1.6, Nav1.1, Nav1.4, Nav1.3 and Nav1.5, respectively). Also exhibits selectivity over a panel of 81 other ion channels, receptors, enzymes and transporters. Blocks spontaneous firing of inherited erythromelalgia (IEM)-derived iPSC sensory neurons in vitro.

Specifications

• Chemical Name or Material: 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate
• CAS: 1430806-04-4
• Quantity: 10 mg
• Target: Voltage-gated Sodium Channel Blockers
• Molecular Formula: C₁₈H₁₂Cl₂FN₅O₃S₂.C₇H₈O₃S
• Formula Weight: 672.56
• Purity: >98%