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Pexidartinib, MedChemExpress

Product Code. 16473197
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Product Code. 16473197

Brand: Medchem Express HY16749

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Description

MedChemExpress Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity.

Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity.

Specifications

Chemical Name or Material Pexidartinib
CAS 1029044-16-3
Color White
Purity Grade Notes Research
Molecular Formula C20H15ClF3N5
Quantity 50 mg
Synonym PLX-3397
Solubility Information DMSO : 100 mg/mL (239.34 mM; Need ultrasonic)
SMILES FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F
Molecular Weight (g/mol) 417.81
Formula Weight 417.81
Percent Purity 98.0%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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