Invitrogen™ PERP Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA518510

Product Code. 11376483

Description

This antibody is predicted to react with canine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.

Specifications

• Antigen: PERP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PERP
• Gene Alias: 1110017A08Rik; dJ496H19.1; HGNC:17637; KCP1; KCP-1; keratinocyte associated protein 1; keratinocyte-associated protein 1; keratinocytes associated protein 1; KRTCAP1; p53 apoptosis effector related to PMP22; p53 apoptosis effector related to PMP-22; p53 apoptosis-associated target; p53-induced protein PIGPC1; PERP; PERP, TP53 apoptosis effector; PIGPC1; RP3-496H19.1; THW; Transmembrane protein THW
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 64065
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q96FX8
• Gene Symbols: PERP
• Immunogen: Synthetic peptide sequence (CLPNYEDDLLGNAK) corresponding to the C-terminus amino acids of PERP (aa 172-186).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG