Perlecan Monoclonal Antibody (A7L6), Invitrogen™

Rat Monoclonal Antibody

Brand:  Invitrogen MA514641

Product Code. 11365113

Description

MA5-14641 targets Perlecan in IF, IHC (F), and IHC (P, F) applications and shows reactivity with Bovine, Human, mouse, and Porcine samples. The MA5-14641 immunogen is mouse EHS laminin preparation.

Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.

Specifications

• Antigen: Perlecan
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P98160, Q05793
• Gene Symbols: HSPG2
• Immunogen: Murine EHS laminin preparation
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Human, Mouse, Pig
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
• Clone: A7L6
• Conjugate: Unconjugated
• Gene: HSPG2
• Gene Alias: AI852380; Basement membrane-specific heparan sulfate proteoglycan core protein; Endorepellin; endorepellin (domain V region); heparan sulfate proteoglycan 2; HSPG; Hspg2; LG3 peptide; LOC313641; Pcn; per; perlecan; perlecan (heparan sulfate proteoglycan 2); perlecan proteoglycan; PLC; PRCAN; RP11-132G19.2; SJA; SJS; SJS1
• Host Species: Rat
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100517288, 15530, 3339, 444872
• Content And Storage: 4° C
• Form: Liquid