PER2 Mouse anti-Human, Clone: GT5310, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA527799

Product Code. 16372304

Description

Positive Control: human Per2-transfected 293T Predicted Reactivity: Mouse (86%), Rat (84%), Bovine (82%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

PER2, also known as Period circadian protein homolog 2, is a mainly nuclear protein that shows nucleocytoplasmic shuttling which is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. PER2 belongs to the basic helix-loop-helix family of transcription factors and contains a PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. PER2 is a component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. This protein is thus essential for generating circadian rhythms and is a negative element in the circadian transcriptional loop which influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Expression of PER2 is fairly wide spread with strong expression in skeletal muscle and pancreas and slight expression in lung. Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS).

Specifications

• Antigen: PER2
• Classification: Monoclonal
• Concentration: 1 mg/ml
• Formulation: PBS with no preservative
• Gene Accession No.: O15055
• Gene Symbols: PER2
• Immunogen: Recombit protein encompassing a sequence within the N-terminus region of human PER2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: GT5310
• Conjugate: Unconjugated
• Gene: PER2
• Gene Alias: FASPS, period circadian clock 2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 8864
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid