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Pellino 1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA532090
Code : PN
Additional Details : Weight : 0.01000kg
Description
Recommended positive controls: THP-1, HL-60. Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (81%), Chicken (99%), Rhesus Monkey (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, μgtimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.Specifications
Pellino 1 | |
Polyclonal | |
Unconjugated | |
PELI1 | |
2810468L03Rik; A930031K15Rik; AA409794; AI586297; D11Ertd676e; E3 ubiquitin-protein ligase pellino homolog 1; Peli1; pellino 1; pellino E3 ubiquitin protein ligase 1; pellino homolog 1; pellino1; pellino-1; Pellino-related intracellular-signaling molecule; PRISM; protein pellino homolog 1; RING-type E3 ubiquitin transferase pellino homolog 1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
57162 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.71 mg/mL | |
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7 | |
Q96FA3 | |
PELI1 | |
Recombinant fragment corresponding to a region within amino acids 17 and 242 of Human Pellino1 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |