PDE6A Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA1721

Product Code. 11538321

Description

PA1-721 detects phosphodiesterase 6 alpha’ (PDE6 alpha’) from sheep, human and bovine retinal extract. PA1-721 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ∽90 kDa protein representing PDE6 alpha’ from sheep and bovine retinal extract. The PA1-721 immunogen is a synthetic peptide corresponding to residues M(16) P Q F A K E Y F D R K L R(29) C of human PDE6 alpha’. This sequence is completely conserved between human, chicken and frog. PA1-721 immunizing peptide (Cat. No. PEP-149) is available for use in neutralization and control experiments.

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Specifications

• Antigen: PDE6A
• Classification: Polyclonal
• Gene: PDE6A
• Gene Alias: Phosphodiesterase 6 Alpha′
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 281973, 5145, 101122024
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: P11541, P16499
• Gene Symbols: PDE6A
• Immunogen: Synthetic peptide corresponding to residues M(16) P Q F A K E Y F D R K L R(29) C of human PDE6 alpha’.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Human, Ovine
• Product Type: Antibody
• Isotype: IgG