Invitrogen™ PDE4B Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA521460

Product Code. 13288848

Description

Recommended positive controls: NT2D1, PC-3, HCT116. Predicted reactivity: Mouse (97%), Rat (96%), Xenopus laevis (86%), Pig (98%), Chicken (89%), Rhesus Monkey (100%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Specifications

• Antigen: PDE4B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PDE4B
• Gene Alias: 3',5'-cyclic AMP phosphodiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; DKFZp686F2182; DPDE4; dunce; dunce-like phosphodiesterase E4; MGC126529; MGC93193; OTTHUMP00000046896; PDE32; PDE4/IVb; PDE4B; Pde4B1; Pde4B2; Pde4B3; Pde4B4; PDEIVB; phosphodiesterase 4B; Phosphodiesterase 4B cAMP-specific (dunce; phosphodiesterase 4B, cAMP specific; phosphodiesterase 4B, cAMP-specific; Phosphodiesterase 4B, cAMP-specific (dunce; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); R74983; RP5-876C12.1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5142
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.72 mg/mL
• Formulation: PBS with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q07343
• Gene Symbols: PDE4B
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human PDE4B. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG