Invitrogen™ PDCD2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5111733

Product Code. 17109653

Descrizione

Immunogen sequence: PLSFLLQVYA PLPGRPDAFH RCIFLFCCRE QPCCAGLRVF RNQLPRKNDF YSYEPPSENP PPETGESVCL QLKSGA Highest antigen sequence indentity to the following orthologs: Rat - 80%, Mouse - 82%.

Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

Specifica

• Antigen: PDCD2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pdcd2
• Gene Alias: AI528543; hypothetical protein MGC63685; Pcd2; PDCD2; programmed cell death 2; programmed cell death protein 2; RP8; RP-8; zgc:63685; zinc finger MYND domain-containing protein 7; Zinc finger protein Rp-8; ZMYND7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5134
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q16342
• Gene Symbols: Pdcd2
• Immunogen: Recombinant Protein corresonding to Human PDCD2. Recombinant protein control fragment (Product #RP-108051).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG