Invitrogen™ PD-L1/4-1BBL Humanized Biosimilar Recombinant Human Monoclonal Antibody

PD-L1/4-1BBL Biosimilar Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30282797	Invitrogen™ MA560147	100 μg
30283110	Invitrogen™ MA560148	1 mg

Description

PD-L1/4-1BBL Biosimilar Recombinant Monoclonal Antibody for SPR, Flow, ELISA, Functional

PD-L1 (Programmed Death-Ligand 1) is a transmembrane protein encoded by the CD274 gene located on chromosome 9p24.1. It is expressed on various cell types, including tumor cells, where it plays a critical role in immune evasion by binding to its receptor PD-1 on T cells, thus inhibiting T cell function and allowing tumor cells to escape immune surveillance. PD-L1 has also been implicated in promoting tumor growth, progression, and radioresistance. On the other hand, 4-1BBL (4-1BB ligand) is a member of the tumor necrosis factor (TNF) superfamily expressed on antigen-presenting cells (APCs) such as dendritic cells, B cells, and macrophages. It is encoded by the TNFSF9 gene on chromosome 19p13.3. 4-1BBL binds to its receptor 4-1BB (CD137) on T cells, providing a co-stimulatory signal that enhances T cell proliferation and survival, as well as cytokine production. The interaction between 4-1BBL and 4-1BB is crucial in the regulation of immune responses, particularly in cancer immunotherapy, where it is leveraged to boost anti-tumor immunity.

Specifications

• Antigen: PD-L1/4-1BBL Humanized Biosimilar
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Lyophilized
• Isotype: VHH
• Target Species: Human
• Primary or Secondary: Primary
• Purification Method: Protein A

• Concentration: 1 mg/mL
• Applications: ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
• Conjugate: Unconjugated
• Host Species: Human
• Regulatory Status: RUO
• Formulation: 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
• Product Type: Antibody