Invitrogen™ PCSK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA529832

Product Code. 13444147

Description

Recommended positive controls: HepG2, HCT116. Predicted reactivity: Mouse (99%), Rat (100%), Zebrafish (93%), Pig (100%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.

Specifications

• Antigen: PCSK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCSK1
• Gene Alias: Att-1; Bdp; BMIQ12; EC 3.4.21.93; Furin homolog; LOW QUALITY PROTEIN: neuroendocrine convertase 1; NEC 1; NEC1; Nec-1; Neuroendocrine convertase 1; PC1; PC3; PCSK1; Phpp-1; Prohormone convertase 1; prohormone convertase 1/3; prohormone convertase 3; propeptide-processing protease; Proprotein convertase 1; proprotein convertase subtilisin/kexin type 1; Protein convertase subtilisin / kexin type I; Protein convertase subtilisin / kexin, type I; SPC3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18548, 5122
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.52 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P29120, P63239
• Gene Symbols: PCSK1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human PC1/3. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG