Invitrogen™ PCID2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA551182

Product Code. 15645105

Description

The antibody detects endogenous levels of total PCID2 protein.

Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.

Specifications

• Antigen: PCID2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCID2
• Gene Alias: A730042J05Rik; CSN12-like protein; F10; fa11f03; HT004; hypothetical protein LOC617943; ik:tdsubc_1e10; im:6909928; PCI domain containing 2; PCI domain-containing protein 2; Pcid2; RGD1307041; RP11-98F14.6; tdsubc_1e10; wu:fa11f03; xx:tdsubc_1e10; zgc:101845
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 234069, 55795
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q5JVF3, Q8BFV2
• Gene Symbols: PCID2
• Immunogen: Fusion protein of human PCID2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG