Invitrogen™ PCDHGA5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA540105

Product Code. 15576791

Description

Recommended positive controls: U87-MG, IMR32, and SK-N-AS cells. Predicted reactivity: Mouse (87%), Rat (85%), Chimpanzee (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Specifications

• Antigen: PCDHGA5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCDHGA5
• Gene Alias: cadherin ME3; CDH-GAMMA-A5; ME3; PCDHGA5; PCDH-GAMMA-A5; protocadherin gamma subfamily A, 5; protocadherin gamma-A5
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 56110
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% Thimerosal; pH 7
• Gene Accession No.: Q9Y5G8
• Gene Symbols: PCDHGA5
• Immunogen: Recombinant protein encompassing a sequence within the Extracellular domain of human PCDHGA5. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG