Invitrogen™ PCDHA2 Monoclonal Antibody (2G12)

Mouse Monoclonal Antibody

Marca:  Invitrogen™ MA522265

Código de producto. 15509102

Descripción

Peptide Sequence: SESLSLVLGK SLDREETAEV NLLLVATDGG KPELTGTVQI LIKVLDVNDN EPTFAQSVYK VKLLENTANG TLVVKLNASD ADEGPNSEIV YSLGSDVSST.

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Especificaciones

• Antigen: PCDHA2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q9Y5H9
• Gene Symbols: PCDHA2
• Immunogen: PCDHA2 (NP_061728, 189 a.a. ~ 288 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Western Blot
• Clone: 2G12
• Conjugate: Unconjugated
• Gene: PCDHA2
• Gene Alias: KIAA0345-like 12; PCDHA2; PCDH-ALPHA2; PCDH-alpha-2; protocadherin alpha 2; protocadherin alpha-2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 56146
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid