Invitrogen™ PCDHA12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA583290

Product Code. 16390245

Description

Immunogen sequence: LNGEISYGIK MILPVSEKCM FSINPDTGEI RIYGELDFEE NNAYEIQVNA IDKGIPSMAG HSMVLVEV Highest antigen sequence indentity to the following orthologs: Mouse - 49%, Rat - 50%.

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Specifications

• Antigen: PCDHA12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCDHA12
• Gene Alias: cadherin-related neuronal receptor 5; Cnr5; Crnr5; KIAA0345-like 2; MGC138485; MGC141932; PCDHA12; Pcdha13; PCDH-ALPHA12; PCDH-alpha-12; protocadherin alpha 12; protocadherin alpha 13; protocadherin alpha-12; rCNRv12
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 56137
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UN75
• Gene Symbols: PCDHA12
• Immunogen: Recombinant protein corresponding to Human PCDHA12. Recombinant protein control fragment (Product #RP-103949).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG