PAX8 Antibody (PAX8/1491), DyLight 488, Novus Biologicals™

Mouse Monoclonal Antibody

Brand:  Novus Biologicals NBP2-54486G

Product Code. 18250504

Description

PAX8 Monoclonal specifically detects PAX8 in Human samples. It is validated for Western Blot, Immunohistochemistry-Paraffin.

Specifications

• Antigen: PAX8
• Classification: Monoclonal
• Conjugate: DyLight 488
• Formulation: 50 mM sodium borate with 0.05% sodium azide
• Gene Symbols: PAX8
• Immunogen: Recombinant fragment (around aa 60-261) of human PAX8 protein (exact sequence is proprietary) (Uniprot: Q06710)
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Test Specificity: Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.
• Content And Storage: Store at 4°C in the dark.

• Applications: Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
• Clone: PAX8/1491
• Dilution: Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
• Gene Alias: paired box 8, paired box gene 8, paired box protein Pax-8, paired domain gene 8
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Research Discipline: Cancer
• Gene ID (Entrez): 7849.0
• Target Species: Human
• Isotype: IgG2b κ