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DiscoverX PathHunter™ U2OS Keap1-NRF2 Nuclear Translocation Cell Line

Product Code. 17323849
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17323849

Brand: DiscoverX 930821C3

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This item is not returnable. View return policy

Description

The PathHunter™ U2OS Keap1-NRF2 Nuclear Translocation Cell Line measures Keap1-NRF2 pathway activation via nuclear translocation of NRF2. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ U2OS Keap1-NRF2 Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the Keap1-NRF2 pathway. This cell line enables assessment of ligand (e.g. methyl CDDO) based pathway activation via detection of resulting NRF2 nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged NRF2 and nuclear localized EA alongside untagged Keap1. Upon pathway activation, induced nuclear translocation of NRF2 leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry NRF2 nuclear translocation
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist CDDO Methyl Ester
Quantity 2 Vials
Target Entry Keap1-NRF2
Accession Number NM_203500.1
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