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DiscoverX PathHunter™ U2OS EphB1 Functional Assay

Product Code. 17373969
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Quantity:
2 Vials
Unit Size:
2 ampoules
Product Code. Quantity unitSize
17373969 2 Vials 2 ampoules
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Product Code. 17373969

Brand: DiscoverX 930893C3

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This item is not returnable. View return policy

Description

The PathHunter™ U2OS EphB1 Functional Assay measures EphB1 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ U2OS EphB1 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated EphB1 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged EphB1 and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Receptor Activation
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist Recombinant Mouse Ephrin-B2Fc Chimera, CF
Quantity 2 Vials
Target Entry EphB1
Accession Number NM_004441.3
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