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DiscoverX PathHunter™ U2OS AXL Functional Assay

Product Code. 17314389
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17314389

Brand: DiscoverX 931105C3

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This item is not returnable. View return policy

Description

The PathHunter™ U2OS AXL Functional Assay measures AXL receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ U2OS AXL Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated AXL dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged AXL and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry SH2 Recruitment
Cell Line U2OS
Format 2 vials
For Use With (Application) Cell Lines
Primary Agonist Gas6
Quantity 2 Vials
Target Entry AXL
Accession Number NM_021913.3
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