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DiscoverX PathHunter™ HEK 293 Tie2 Functional Assay

Product Code. 17384249
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17384249 2 Vials 2 ampoules
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Product Code. 17384249 Supplier DiscoverX Supplier No. 931024C1

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Description

The PathHunter™ HEK 293 Tie2 Functional Assay measures Tie2 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ HEK 293 Tie2 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated Tie2 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged Tie2 and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry SH2 Recruitment
Cell Line 293H
For Use With (Application) Cell Lines
Primary Agonist Angiopoietin-2
Quantity 2 Vials
Target Entry Tie2
Accession Number NM_000459.4
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