DiscoverX PathHunter™ HEK 293 GPR20 β-Arrestin Orphan GPCR Cell Line

Artikelnummer. 17353119

Marke: DiscoverX 930405C1

Beschreibung

The PathHunter™ HEK 293 GPR20 β-Arrestin Orphan GPCR Cell Line measures GPR20 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ GPR20 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR20 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged GPR20 and EA-tagged β-Arrestin 2. Activation of GPR20 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Orphan receptor with unknown ligand.

Spezifikation

• Assay Entry: β-Arrestin recruitment
• Cell Line: 293H
• For Use With (Application): Cell Lines
• Quantity: 2 Vials
• Target Entry: GPR20
• Accession Number: NM_005293