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DiscoverX PathHunter™ CHO-K1 CNR1 β-Arrestin Cell Line

Product Code. 17354089
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17354089 2 Vials 2 ampoules
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Product Code. 17354089 Supplier DiscoverX Supplier No. 930959C2

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Description

The PathHunter™ CHO-K1 CNR1 β-Arrestin Cell Line measures CNR1 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ CNR1 β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CP 55,940) based activation of CNR1 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged CNR1 and EA-tagged β-Arrestin 2. Activation of CNR1 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry β-Arrestin Recruitment
Cell Line CHO-K1
For Use With (Application) Cell Lines
Primary Agonist CP 55,940
Quantity 2 Vials
Target Entry CNR1
Accession Number AY225225
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