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DiscoverX PathHunter™ CCR4 Total GPCR Internalization U2OS Cell Line

Product Code. 17323889
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17323889

Brand: DiscoverX 930845C3

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This item is not returnable. View return policy

Description

The PathHunter™ CCR4 Total GPCR Internalization U2OS Cell Line measures CCR4 (GPCR) internalization via early-endosome localization. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ CCR4 Total GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. CCL22/MDC) based internalization of CCR4 via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses PK-tagged CCR4 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the CCR4 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Receptor Internalization
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist Recombinant Human MDC (CCL22)
Quantity 2 Vials
Target Entry CCR4
Accession Number AY322539
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